The global prevalence, and highly gendered nature, of sex trafficking and related forms of sexual exploitation of women and girls, poses serious challenges which the international community must meet. These challenges, and a range of potential solutions are considered by a high level International panel of both State and Civil Society actors from a range of jurisdictions. Representatives from Ireland, the Council of Europe, Mexico, Lebanon and the USA reflect on current risk factors including: precarious migration, rural poverty, and systemic gender inequalities, and present a range of service, policy and legislative approaches designed to combat these terrible human rights violations of women and girls.